Consequential damages of cryptopyrroluria

For what problems or complications resulting cryptopyrroluria?

A person who retires cryptopyrrol increased in the urine, is called a pyrrolic person. After all, what is known so far, the pyrrolic person is different.

For our “normal” citizens he is often suspect – not quite normal. A hypochondriac perhaps.

As Hippocrates divided the various types of temperament, he might have the choleric, melancholic, phlegmatic and sanguine superadded the pyrrolic person.

As the representative of temperament, not only the hyperactivity, but also the hypochondriac. It is those people who constantly missing something and that is constantly busy with their illnesses.

For the doctors who work with the cryptopyrroluria, the pyrrolic person is a person who has no vitamin B6 reserves. Dr. Bodo Kuklinski says: “Health is made in the cell. In the smallest chemical laboratory of our body certain substances must be present, that we humans can work, that we are healthy at the levels of body, soul and spirit. Everything depends on the correct composition. The pyrrolic person loses vitamin B6 and zinc in the urine.

Our body is usually able to pay all repair operations in the penetration of pollutants, viruses or bacteria himselve. Not so the pyrrolic person. He suffers from birth to life from a chronic vitamin B6 and zinc deficiency, which can not be compensated by a normal, healthy mixed diet.

The consequences may go unnoticed, as long as these people live with a low level of pollutants, work and eat reasonably natural, and are subject to severe mental and physical strain or stress.

Today’s living conditions, diet and pollution factors are risk factors that lead to the unmasking of pyrroluria”.

It is striking that pyrrolic persons on the one hand can not be loaded. Everything is too much, they are lazy, phlegmatic, have fear, panic, depression, suicidal ideation and suicide risk, hallucinations, unreality.

On the other hand, there are pyrrolic persons showing no psychological problem. As far as their health carry, they are creative and active. Many pyrrolic persons realize ideas and projects into old age, to have consisted mostly without appropriate checks in work or study.

Both, the non-load and the overactive pyrrolic person, are often hectic and live in chaos and suffering from cognitive disorders.

The following medical conditions may favor a cryptopyrroluria:

  • chronic diseases such as allergies, eczema, psoriasis, intestine, lung and lung diseases
  • woman suffering
  • Herpes simplex virus diseases
  • cervical syndrome
  • Childhood illness (typical) polyps, celiac disease
  • cancer
  • Mycosis (fungal) and parasites in the body
  • Multi-organ disease (patients with multi-organ disease, the diagnosis could not be clarified)
  • Type 1 diabetes
  • MCS (Multiple Chemical Sensitivity), heavy metal poisoning
  • Mental illness, depression, psychosis, schizophrenia
  • Addiction, alcohol and nicotine intolerance, intolerance of anesthesia

There are plenty of cases of pyrrolic children, retarded as the land despite high intelligence in the special school.

Some pyrrolic persons suffer from eating disorders (anorexia), nervous exhaustion, insomnia, strong internal tensions, uncontrolled behavior, sudden disengagement, aggression, amnesia (disturbed memory), autism, epilepsy, schizophrenia, paranoid psychosis or halluzinoider.
The pyrrolic person prefers in the age solitude, seclusion and is considered a nerd.

How does it happen to all these disturbances?

Previous studies on approximately 800 patients showed a positive correlation between pathologically elevated cryptopyrrole values and nitrosative stress.

Nitrosative stress occurs when caused by an increased production more nitrogen-containing compounds such as nitric oxide (NO) are present in the organism than can be degraded. This can lead to changes in protein structures and thus to the disruption of normal protein functions.

People with cryptopyrroluria show increased NO (nitric oxide) production, measurable by pathologically high citrulline values in the urine or increased NO concentrations of the exhaled air.

Citrulline is an amino acid that is a by-product of NO synthesis from:

L-arginine + oxygen = NO + citrulline

is generated. NO and citrulline are not stable values. They show very rapid fluctuations, particularly under physical stress, which are known to be associated with an increased oxygen conversion to metabolism, especially in the mitochondria.

This finding leads to enormous consequences for the diagnosis, treatment and assessment of pyrroluria not as an independent disease pattern, but as a companion symptom of a multidisciplinary disease, since this disorder can manifest itself in many parts of the body.

NO occurs in four different ways in the organism:

  • Endothelial NO synthesis (eNOS). NO is formed in the inner walls of the blood arteries.
  • Neural NO synthesis (nNOS), the built in the nerve cell.

Both NO forms serve as nerve messengers in the transmission of neuronal signals.

  • NO-gas (iNOS) is also required by the immune system to fight pathogens. This inducible form of the NO gas increases with infections by bacteria, viruses, parasitoses, but also by chemical loads.
  • Mitochondrial NO synthesis (mtNOS). Mitochondria form NO as a metabolic regulator for cellular energy (ATP) production.

NO has the property of binding to and inhibiting iron, especially iron-containing enzymes. This binding is reversible and can be solved by high oxygen pressure in the blood. This also explains the oxygen starvation of affected patients.

The biochemical effects of increased NO gas production are:

1. Inhibition of iron-containing enzymes in the respiratory chain of cellular energy production. With this inhibition less ATP is formed, but the blockade also means an intensified superoxide formation in the mitochondria, which is further intensified by physical stress and therefore by increased metabolism.

2. One of the iron-containing enzymes is the liver hydroxylase, which accomplishes the conversion of cholesterol into bile acids. A blockade leads to an early cholesterol rise, which is completely resistant against dietetic changes and has nothing to do with cholesterol-rich diet.

Since inside the mitochondria the ATP production take place, massive metabolic deficits develop, which then manifest themselves clinically in the form of lactose intolerance, but above all in a chronic energy deficit.

This is particularly noticeable in the energy-dependent organs such as the central nervous system and the musculature. Affected persons suffer from a chronic energy deficit, are more easily exhaustible, need longer rest periods, and concentration is only possible in a limited time.

Endurance activities, which require particularly energy from the fatty acid oxidation, are hardly possible.

The constant hunger sensation forces the affected person to eat, the excess nutrients, however, often block the energy production, so that constant eating does not correct the energy deficit, but rather reinforces it.

Energy from carbohydrates can not be used caused by the B vitamin deficiency, which leads to an inevitable increase in weight, while proteins and fatty acids can be utilized more energetically (for example, meat and fish).

Clinical consequence is the tendency to increased fat intake, chronic hunger, chronic hypoglycemia and tendency to elevated cholesterol.

Other consequences are hereditary disorders of protein production, so that hereditary diseases can occur, also chronic immunosuppression with susceptibility to infections, thyroid dysfunction, hereditary forms of depression, ADHD, autoimmune diseases.

Cryptophyrroluria is inheritable.

The chronic energy deficit consequently manifests itself in a chronic fatigue and exhaustion syndrome.

The amino acid citrulline has the property of attaching itself to certain proteins, for example fibrinogen. This citrullinated fibrinogen acts as an antigen and triggers autoimmune responses, which means the immune system is misdirected and now attacks the body’s own tissue, especially in the joints and the spine, resulting in chronic alternating joint complaints or even chronic lumbar spine pain which have nothing to do with physical stress.

If these processes occur in the long term, a rheumatoid arthritis may arise.

The blockade of the mitochondrial energy metabolism leads to the mitochondria developing into free-radical guns that trigger oxidative stress. Now, more free radicals also attack the tissue. Alone with an increased occurrence of free radicals, modern medicine brings about 200 diseases in a direct context.

If chemical stresses are now added, Th 1 lymphocytes intensify the release of interferon, which is a powerful stimulus for further iNO synthesis.

This means that pyrrolians are chemically sensitive persons.

The chronic energy deficit forces the cells to activate their survivability by using their secondary “emergency generators” such as the fermentation metabolism.

This promotes the formation of cancer cells. In addition, NO in the body leads to an increased formation of nitrosamine, which leads to an increased risk of genetic changes.

NO gas and free radicals form a lethal cocktail (peroxinitrite).

Peroxinitrite is highly toxic, oxidizing and accumulates with amino acids such as serotonin. Adapting to phenylanine leads to tyrosine deposits, so that autoimmune reactions can also be triggered, for example in the thyroid gland and the nerval transmitters. A typical example is Hashimoto’s thyroiditis.

The attached products are nitrosed amino acids, e.g. Nitrotyrosine, which are now also detectable as citrullinated peptides.

Peroxinitrite and nitrosated amino acids are found very early in chronic inflammatory processes, particularly in the nervous system. Examples are multiple sclerosis (autoimmune disease of the nervous system) or amyotrophic lateral sclerosis.

This leads to a progressive and irreversible damage or degeneration of the nerve cells which are responsible for the muscle movements. However, peroxynitrite and nitrosated amino acids are also detectable in arteriosclerosis and other diseases.

As a result, disturbances of the hormonal balance and the neurotransmitters in the brain develop.

In the case of chronic increased peroxinitrite formation, this also increases the risk of autoimmune diseases of all kinds.

The irreversible inhibition of the mitochondrial function and the duration of bombardment by oxygen radicals also damage the cells and the DNA of the nucleus, as well as damage to the mitochondrial genome.

Not only the cell nuclei have genes. The mitochondria also have a ring-shaped genome consisting of 37 DNA molecules that are not repairable due to a low histone protein content.

The damage to the mitochondrial genome does not occur immediately, but after a certain latency period. The cause is that each mitochondrial gene has approximately 500 to 1,000 copies.

If 5 to 10% of the copies are damaged, there is still no serious loss of clinical performance. If this increases to 40 or 50%, the performance of the mitochondrial function is already noticeable.

The most common are pyruvate kinase disorders with carbohydrate utilization disorders. Carbohydrates from sugar and food can not be used energetically. They lead to lactic acidosis. With the formation of this lactic acidosis, metabolic disorders and the exhaustability of the patients are intensified.

Mitochondrial genetic damage is inherited on the mother’s side, not by the father, since the mitochondria have an independent multiplication and are passed on via the ovule.

Cryptopyrroluria shows strong fluctuations during the day and is to be regarded as a stress factor for the nervous system and leads to the known deficits of vitamin B 6 and zinc.

A chronic energy deficit in the nervous system often leads to additional activations of C nerve fibers.

These surrounds the mast cells in a network-like manner, so that in the case of irritation histamine is also released. Chronic elevated histamine excretion has a stimulating effect on the brain; peripheral it is a matter of time when allergies develop against external factors (pollen, dust, etc.).

The affected persons do not suffer from allergic reactions due to the pollen, or the mites, but from increased histamine release and a disturbed histamine degradation.

For the breakdown of histamine the organism needs copper and vitamin B 6 . If little meat is eaten, those affected get additionally into a vitamin B 6 , vitamin B 12 and methionine deficit. Sufficient methionine can only be absorbed by the body via meat.

This means that in the brain and peripherally, not enough histamine can be degraded.

A zinc deficiency leads to the functional weakness of the Zn / Cu superoxide dismutase. In addition, glutathione-S-transferases become ineffective in zinc deficiency. In those affected, the cell-internal detoxification is now blocked and therefore they are more sensitive to foreign and harmful substances.

In addition, NO also inhibits the cytochrome P450 enzymes, which are very important for phase I detoxification. Here, for example, is determined how quickly a smoker is affected by lung or bronchial cancer decides.

In summary we conclude that cryptopyrroluria is only a symptom of a much more serious disturbance at the cellular level, which causes systemically deficits in the performance of the organs and becomes ineffective in multi organ level when disregarded.

Thus, mothers with cryptopyrroluria show an increased risk of pregnancy complications. NO gas activates the uterine contractions and opens the mouth of uterus. The consequences are premature births.

Other symptoms of cryptopyrroluria are an increased risk of neurodermatitis, nasal polyps, middle ear inflammations, bronchitis, allergies.

From all of the above-mentioned facts it follows that the treatment of pyrroluria can be carried out with B vitamins, zinc and other micronutrients.

This is only possible by micronutrients, which compensate for the existing deficits and thus normalize the metabolism on a broad front.

If we consider the ADHD (attention deficit disorder) occurring during childhood, symptoms of neurodermatitis, exhaustion, pain and allergy, these are not isolated diseases, but are always the expression of cryptopyrroluria.

A causative therapy is therefore only possible with vital substances, but never by symptomatic treatment such as Ritalin, corticoids or other drugs acting on the immune system.

Numerous dipeptidases of the small intestine (protein-degrading enzymes) have only a zinc-dependent effect. So-called milk intolerances have their cause here. Since, in cryptopyrroluria, decomposition disorders of lactose, fructose and gluten are also inevitable, the associated intestinal symptoms also develop.

Disorders of the thyroid, adrenal gland and pancreas

According to studies by Kamsteeg, the level of the hormone TSH is below 2 mU / l in 60% of those affected by the KPU, and 85% in women. The range between 0.35 and 2 mU / l is within the school medical standard, but Kamsteeg observes deviations of other laboratory parameters in these values for middle-aged people.

The “control hormone” TSH distributed by the pituitary gland regulates the distribution of the thyroid hormones, which in turn affect the activity of other endocrine glands. For example, they regulate insulin release from the pancreas into the glucose metabolism and influence the activity of the adrenal glands.

Low TSH levels may cause dysfunction of the thyroid, adrenal, pancreas and stomach.

Disorders of the thyroid gland are particularly frequent, usually in the form of a thyroid gland or Hashimoto thyroiditis. A subfunction of the adrenal glands is also often observed.

It makes itself felt by:

  • Frequent urination
  • Low or strongly changing blood pressure
  • Chronic infections
  • Rheumatoid arthritis
  • Complaints of upper air passages
  • Severe exhaustion

Autoimmune diseases

People with KPU are above average affected by autoimmune diseases after Kamsteeg. From Kamsteeg’s perspective this is caused by the bioactive (including porphyrinogenic) substances that are not disposed of by the liver, which accumulate in the tissue, react with the cell membranes and are subsequently regarded as non-organisms by the immune system. Another theory, led by Kamsteeg, regards the destruction of arachidonic acid by free radicals as a common cause for the development of autoimmune diseases.

Kamsteeg often has found an association of KPU with the autoimmune diseases Hashimoto-Thyreoiditis and Primary biliary cirrhosis (PCB). Both diseases are often manifested during or after pregnancies or after virus infections. Attention: Due to the “healthy” yellow-brown skin color of the PCB patients there is the danger of a wrong assessment of the health condition.

Disorders of histamine metabolism

“Disorders of histamine metabolism” express in dissentient histamine blood levels, are common in pyrrolics, can cause a large number of very different symptoms, among others a histamine intolerance, and delay an improvement in the condition considerably.

Disorders in glucose metabolism

Often there is a chronically low or unstable blood glucose level in the case of pyrrolics, with frequent blood glucose relapses, referred to as functional, reactive or hypoglycaemia. According to Kamsteeg, this can go into glucose intolerance or prediabetes, particularly in women aged 30 years and over.

Food intolerances

In the case of pyrroluria, food intolerances frequently occur. Kuklinski explains this by the fact that numerous dipeptidases of the small intestine (protein-degrading enzymes) have only a zinc-dependent effect, and that this necessarily leads to degradation of lactose, fructose and gluten or to pseudo-allergies to protein (for example cow’s milk). Thome argues that the immune system does not work optimally as a result of the protein metabolic disorder in pyrroluria, since antibodies also consist of proteins.

Particularly frequently (according to Kamsteeg) a gluten intolerance occurs, but without a celiac / sprue. The overwhelming number of 5,500 women examined by KEAC showed this form of gluten intolerance. Some forum members report improvement of especially mental symptoms by avoiding gluten. The fructose intolerance is also frequent.

Intolerances against casein and soy protein are also observed in the context of pyrroluria, as well as IgG- or IgG (4) -mediated food intolerances. In the case of intestinal complaints, hay fever, urticaria, etc., screening of a large number of foodstuffs is possible to research this type of intolerance.

Source : Better Living with Melasses – J. Rinne – Syntropia Verlag